Mubasher: Japanese indices ended Wednesday on a lower note for the second session in a row, according to Market Watch data
The Nikkei index was 1.88% lower to 16,083.11 points.
The broader Topix fell by 2.17% to 1,272 points.
By 7:30am GMT, Yen rose against the US dollar by 0.18% to 101.07 per dollar.